Clinical Reports & Studies

At JBP, we uphold quality built on decades of scientific research and clinical evidence.

Placental extract has been widely studied for use in pharmaceuticals, cosmetics, health supplements, and pet nutrition.
Below are selected studies demonstrating its proven efficacy and safety.

A. Pharmaceuticals

Biological effects of human placental extracts -

variations in manufacturing methods and compositions

Journal of Publication：Front Pharmacol.
Publication Date：2025 Dec 10
Authors：Yikelamu Alimu, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/41451368/

Efficacy and Safety of Placental Extract on Menopausal Symptoms: A Systematic Review

Journal of Publication：Nutrients.
Publication Date：2025 Dec 10
Authors：Sára Papp, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/41470802/

Revitalizing liver health: Human placental extract shows promise in chronic liver disease management

Journal of Publication： World J Clin Cases.
Publication Date：2025 Oct. 26
Authors：Yang Liu, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/41113079/

Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells

Journal of Publication：Regen Ther.
Publication Date：2025 Feb.
Authors：Natsuki Ishikawa, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/39991509/

Human placental extract rescues hippocampal damage associated with cognitive impairment in diabetic male rats through antioxidative, anti-inflammatory, and neuromodulatory activities

Journal of Publication：Metab Brain Dis.
Publication Date：2025 Jun.
Authors：Shreen Matar, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/40522516/

Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury

Journal of Publication：Regen Ther.
Publication Date：2024 Nov.
Authors：Fereshteh Talebpour Amiri, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/39687331/

Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model

Journal of Publication：J Microbiol Biotechnol.
Publication Date：2024 Oct.
Authors：Jung Ok Lee, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/39252632/

Effectiveness and safety of hominis placental pharmacopuncture for chronic temporomandibular disorder: A multi-center randomized controlled trial

Journal of Publication：Integr Med Res.
Publication Date：2024 Jun
Authors：Kyoung Sun Park, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/38779539/

A farewell to phlebotomy-use of placenta-derived drugs Laennec and Porcine for improving hereditary hemochromatosis without phlebotomy: a case report

Journal of Publication： J Med Case Rep
Publication Date：2022 Jan 23
Authors：Yuki Hamada, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/35065677/

Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis

Journal of Publication：Biomed Res.
Publication Date：2020
Authors：Akihiro Yamauchi, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/32092735/

Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice

Journal of Publication：Heliyon.
Publication Date：2019 Oct 13
Authors：Akihiro Yamauchi, et al
Product Category：Pharmaceutical
Linkhttps://pubmed.ncbi.nlm.nih.gov/31667435/

Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism

Journal of Publication：Heliyon.
Publication Date：2019 May 10
Authors：Akihiro Yamauchi, et al
Product Category：Pharmaceutical
Link：https://pubmed.ncbi.nlm.nih.gov/31193082/

B. Cosmetics＆Supplements

Combined ophthalmic therapy and equine placental extract supplementation to treat corneal perforation in geriatric cats: A case report in the absence of surgical intervention

Journal of Publication：Open Vet J.
Publication Date：2025 Oct 31
Authors：Takae Natori, et al
Product Category：Supplement for Pets
Link：https://pubmed.ncbi.nlm.nih.gov/41246386/

Placental Extract Inhibits Melanogenesis by Inducing the Proteasome-Dependent Degradation of Tyrosinase and TRP-1

Journal of Publication：Biol Pharm Bull.
Publication Date：2025 Oct
Authors：Mie Moriya
Product Category：Cosmetics
Link：https://pubmed.ncbi.nlm.nih.gov/41062307/

Supplementation with porcine placenta extract reduces negative emotions and enhances positive emotions in healthy adults: a randomized, double-blind, placebo-controlled study

Journal of Publication：Front Nutr.
Publication Date：2025 July
Authors：Naoya Morita, et al
Product Category：Supplements
Link：https://pubmed.ncbi.nlm.nih.gov/40771219/

The equine placental extract ameliorates renal damage in mice with adenine-induced chronic kidney disease by inhibiting indoxyl sulfate production

Journal of Publication：Open Vet J.
Publication Date：2025 July
Authors：Koji Sugimoto, et al
Product Category：Supplement for Pets
Link：https://pubmed.ncbi.nlm.nih.gov/41036361/

Porcine Placental Extract Improves the Lipid Profile and Body Weight in a Post-Menopausal Rat Model Without Affecting Reproductive Tissues

Journal of Publication：Nutrients.
Publication Date：2025 Mar
Authors：Tugsjargal Purevdorj, et al
Product Category：Supplements
Link：https://pubmed.ncbi.nlm.nih.gov/40290014/

Early Effects of Porcine Placental Extracts and Stem Cell-Derived Exosomes on Aging Stress in Skin Cells

Journal of Publication：J Funct Biomater.
Publication Date：2024 Oct.
Authors：Takaaki Matsuoka, et al
Product Category：Cosmetics
Link：https://pubmed.ncbi.nlm.nih.gov/39452604/

Supplementation of equine placenta extract on corneal wound in two dogs: Case report

Journal of Publication：Open Vet J.
Publication Date：2024 Jun.
Authors：Tadashi Nakagaki, et al
Product Category：Supplements for Pets
Link：https://pubmed.ncbi.nlm.nih.gov/39055764/

Evaluating the Impact of a Cream Containing Horse Placental Extract on Eye Corner Wrinkles in Healthy Women: Single-Blind Comparative Study

Journal of Publication：JMIR Dermatol.
Publication Date：2023 Nov 15
Authors：Tsuyuko Watanabe, et al
Product Category：Cosmetics
Link：https://pubmed.ncbi.nlm.nih.gov/37966883/

Supplementation of equine placenta extract on corneal wound in two dogs: Case report

Journal of Publication：Open Vet J.
Publication Date：2024 Jun.
Authors：Tadashi Nakagaki, et al
Product Category：Health Supplement for Pets
Link：https://pubmed.ncbi.nlm.nih.gov/39055764/

Successful treatment of ascites accumulation and diarrhea associated with protein-losing enteropathy with oral equine placenta extract supplementation in a dog: A case report

Journal of Publication：Open Vet J.
Publication Date：2022 Sep-Oct
Authors：Naoki Fukushima, et al
Product Category：Health Supplement for Pets
Link：https://pubmed.ncbi.nlm.nih.gov/36589412/

Equine placental extract supplement as a night barking remedy in dogs with cognitive dysfunction syndrome

Journal of Publication：Vet Med Sci.
Publication Date：2022 Sep.
Authors：Tatsuya Amano, et al
Product Category：Health Supplement for Pets
Link：https://pubmed.ncbi.nlm.nih.gov/35921448/

Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice

Journal of Publication：J Pharmacol Sci.
Publication Date：2012
Authors：Kazuhiro Takuma, et al
Product Category：Health Supplements
Link：https://pubmed.ncbi.nlm.nih.gov/22971911/

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Clinical Reports & Studies

​At JBP, we uphold quality built on decades of scientific research and clinical evidence.

A. Pharmaceuticals

B. Cosmetics＆Supplements

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At JBP, we uphold quality built on decades of scientific research and clinical evidence.